Beyond the Isoprene Pattern: Bifunctional Polyene Cyclizations
نویسندگان
چکیده
منابع مشابه
Bifunctional abietadiene synthase: mutual structural dependence of the active sites for protonation-initiated and ionization-initiated cyclizations.
Abietadiene synthase from grand fir catalyzes two sequential, mechanistically distinct cyclizations, of geranylgeranyl diphosphate and of copalyl diphosphate, in the formation of a mixture of abietadiene isomers as the committed step of diterpenoid resin acid biosynthesis. Each reaction is independently conducted at a separate active site residing in what were considered to be structurally dist...
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Dental Update – May 2000 165 Abstract: As both humans and fungi are eukaryotic organisms, antifungal agents affect their cellular metabolism. Thus, a relatively few antifungals with minimal toxicity and side-efects are available compared with a plethora of antibacterials. These agents currently prescribed in dentistry belong to two major groups, the polyenes (nystatin and amphotericin B) and th...
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The rsuiical cyclizations of N-aziridinyl imines and alkyl azides provided reliable methods for the formation of fiveand six-membered carbon-centered and nitrogen-centered radicals from acyclic precursors. NAziridinyl imino and azido groups were utilized as radical precursors as well as radical acceptors in radical cyclization. Furthermore, intramolecular addition of aminyl radicals to carbonyl...
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ژورنال
عنوان ژورنال: Chemistry – A European Journal
سال: 2021
ISSN: 0947-6539,1521-3765
DOI: 10.1002/chem.202005157